【万象城AWC(中国)基因检测】文心一言中基因测试中关于CISH的知识所包含的内容

基因检测的序列名称：

CISH

人体基因序列变化与疾病表征数据库中的基因代码：

1154

人体基因序列数据库中国际研讨名称全称

cytokine inducible SH2 containing protein

中国数据库中基因全称：

细胞因子诱导性SH2含蛋白

基因检测报告英文版基因简介

The protein encoded by this gene contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of the erythropoietin receptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

基因突变所影响的基因信息

该基因编码的蛋白质包含一个SH2域和一个SOCS框域。因此，该蛋白质属于细胞因子诱导的STAT抑制剂（CIS），也称为细胞因子信号传导抑制因子（SOCS）或STAT诱导的STAT抑制剂（SSI）蛋白质家族。已知CIS家族成员是细胞因子诱导的细胞因子信号传导的负调节剂。IL2，IL3，GM-CSF和EPO可以在造血细胞中诱导该基因的表达。蛋白酶体介导的该蛋白的降解已被证明与促红细胞生成素受体的失活有关。已发现该基因的编码不同同工型的多个转录物变体。[由RefSeq给予，2008年8月]